Usually 12 to 15 hours is the half-life of modafinil, the active component in drugs like Modvigil 200 and Modalert 200. This means that it takes roughly this long for half of the drug to be removed from your system. Up to 48 hours after usage, modafinil may remain in your system depending on your metabolism, liver function, and dose. Modafinil usually has effects like increased alertness and concentration that last 10 to 12 hours, but it may also show up in blood, urine, and saliva tests for a longer time.
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