What drug keeps you awake the longest?
Many medications are known to keep users awake for long stretches of time; however, there are trade-offs associated with their duration. Commonly used prescription wake-promoters, such as modafinil and armodafinil, have less stimulant adverse effects and persist for 10 to 15 hours. Modafinil-containing products like Modvigil 200 are frequently used for prolonged alertness rather than intensity. Stronger stimulants, such as amphetamines or methamphetamine, may keep a person awake for much longer—sometimes up to 24 hours—but they come with major hazards, such as addiction, cardiac difficulties, and mental health problems. When taking wakefulness medications on a daily basis, physician monitoring is crucial since even long-acting medications can interfere with sleep cycles.

